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Serum samples were obtained from 59 persons who had recovered from
infection with the B.1.1.529 (omicron) BA.1 variant: 15 vaccinated persons
without previous severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection (Panel A); 18 unvaccinated persons without previous SARS-CoV-2
infection (Panel B); 11 vaccinated persons with previous infection with
the D614G (wild-type), B.1.1.7 (alpha), or B.1.617.2 (delta) variant (Panel
C); and 15 unvaccinated persons with previous infection with the wild-type,
alpha, or delta variant (Panel D). Serum samples were obtained from each
person 5 to 42 days after the first positive polymerase-chain-reaction
assay during infection with the omicron BA.1 variant. Samples were analyzed
for 50% neutralization titers (IC50) with the use of replication-competent
wild-type, alpha, beta, P.1 (gamma), delta, or omicron BA.1 SARS-CoV-2
isolates. Individual values (circles) and mean titers (bars) are shown.
Samples from the same person are connected by lines. Titers below 1:16
(dotted lines) are regarded as negative. In Panels B and D, the numbers
above the bars indicate the proportions of samples that were positive for
neutralizing antibodies against the respective variant. In Panels A and
C, all the samples were positive for neutralizing antibodies against all
the variants. |
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